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Comparison of Efficacy of cocktail injection during surgery around the knee joint With And Without Steroid For Pain Control In Post-Operative Period In Patients Undergoing Total Knee Replacement - Randomized controlled trial

A Double-Blind Randomised Control Trial To Compare Efficacy Of Intra-Operative Periarticular Cocktail Infiltration Regimen With And Without Steroid For Pain Control In Post- Operative Period In Patients Undergoing Total Knee Arthroplasty.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/038319
Enrollment
32
Registered
2021-11-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention1: Steroid Group: Steroid group will receive infiltration with local anaesthetic of 0.75% ropivacaine 30ml, 1:1000 adrenaline 0.5ml and 40mg of methylprednisolone acetate 1ml along with no

Sponsors

Nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients in whom Total Knee Replacement is done under general anaesthesia who consents for the study and follow up. 2) Age group 40 to 80

Exclusion criteria

Exclusion criteria: 1) History of allergy to the medications used in the study 2) Abnormal renal or liver function tests 3) Patients with stress fractures 4) Patients with intra-operative fractures 5) Previous history of steroid injection into the knee joint 6) Patients undergoing revision surgery 7) Patients undergoing anaesthesia other than general anaesthesia 8) Patients taking any medication for psychiatric illness will be excluded

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of steroidal regimen over non-steroidal regimen as multimodal periarticular cocktail infiltration for post-operative pain relief in patients undergoing total knee replacement.Timepoint: POD 0 - 3hrs, 6hrs, 12hrs, POD 1, POD 2, POD 3, POD 7—

Secondary

MeasureTime frame
To see the effect in early range of motion in patients undergoing total knee arthroplasty pre and post-operatively.Timepoint: 7 days—

Countries

India

Contacts

Public ContactDr Anup Kumar

All India Institute of Medical Sciences

dr.anup@gmail.com9431890411

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026