Norepinephrine, Ephedrine and Phenylephrine- A comparative Study on treatment of maternal hypotension after spinal anaesthesia in Pre eclamptic patient undergoing caesarean section

A comparative study on Norepinephrine, Ephedrine and Phenylephrine for treatment of spinal anaesthesia induced maternal hypotension in pre eclamptic patient undergoing caesarean section

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/11/038284

Enrollment

108

Registered

2021-11-26

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Control Intervention1: Ephedrine: 4 mg Intravenous bolus dose given after every hypotensive episode post spinal anaesthesia in pre eclamptic patient undergoing caesarean section Control Intervention2:

Eligibility

Inclusion criteria

Inclusion criteria: 1.Diagnosed with Pre-eclampsia 2.Singleton Pregnancy 3.ASA physical status II 4.Undergoing Elective Lower Segment Caesarean section under Spinal Anaesthesia

Exclusion criteria

Exclusion criteria: 1.Patient Refusal to study 2.ASA PS III or above 3.Suspected fetal compromise 4.Eminent signs of Eclampsia 5.Chronic hypertension 6.Twin/multiple gestation 7.Comorbid with diabetes mellitus or cardiovascular disease 8.Drug allergy 9.Contraindications to neuraxial analgesia

Design outcomes

Primary

Measure	Time frame
Maternal hemodynamics: Heart Rate Systolic blood Pressure Diastolic blood pressure Mean arterial pressure Neonatal outcomes : Apgar scoreTimepoint: Maternal hemodynamics at 0 mins, 2 mins, 4 mins, 6 mins 8 mins, 10mins, 12 mins, 14 mins, 16 mins, 18 mins, 20 mins, 25 mins, 30 mins, 40 mins, 50 mins, 60 mins Apgar score at 1 min and 5 min	—

Secondary

Measure	Time frame
1. Incidence of intraoperative episodes of tachycardia, bradycardia, hypertension 2. Total dosage of vasopressors required 3. Number of hypotensive episodes 4. Maternal side effects like vomiting and nauseaTimepoint: at 0 mins, 2 mins, 4 mins, 6 mins 8 mins, 10mins, 12 mins, 14 mins, 16 mins, 18 mins, 20 mins, 25 mins, 30 mins, 40 mins, 50 mins, 60 mins	—

Countries

India

Contacts

Public ContactPRATEEK PURKAYASTHA

Kasturba Medical College, Mangalore

sureshyv63@gmail.com9845085108

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026