To assess whether pregabalin and amitriptyline can modify postoperative pain when given before surgery

Comparative study of oral pregabalin versus oral amitriptyline as preemptive analgesic agent in patients undergoing inguinal hernioplasty surgeries under spinal anaesthesia.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/11/038199

Enrollment

Registered

2021-11-23

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: C.Pregabalin: 75mg single dose 2 hours before surgery Intervention2: T.Amitriptyline: 10mg single dose 2 hours before surgery Control Intervention1: T.Ranitidine(placebo): 150 mg single

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anaesthesiologists physical status 1 and 2 2.Patients posted for elective inguinal hernioplasty surgery

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Known sensitivity to Pregabalin and Amitriptyline 3.History of seizure disorder 4.Known psychiatric disorder 5.History of chronic pain and chronic daily intake of analgesic 6.Liver or renal disease 7.History of drug or alcohol abuse 8.Pregnancy and breastfeeding mothers

Design outcomes

Primary

Measure	Time frame
To evaluate the effectiveness of pregabalin and amitriptyline in the prevention of postoperative painTimepoint: 24 hours post surgery	—

Secondary

Measure	Time frame
Side effects of pregabalin and amitriptylineTimepoint: 24 hours post surgery;To measure intensity of acute postoperative painTimepoint: 24 hours post surgery;Use of rescue analgesicsTimepoint: 24 hours post surgery	—

Countries

India

Contacts

Public ContactDr Anitha

Bundelkhand medical college

freegasflow@gmail.com9424422744

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026