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To see the adjunctive use of HD-tACS as a tool to improve cognitive functioning in schizophrenia patients.

Efficacy of Theta Frequency HDtACS for Cognitive Deficits in Schizophrenia: A Randomized Double-Blind Sham-Controlled Study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/038189
Enrollment
40
Registered
2021-11-23
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F20- Schizophrenia

Interventions

Intervention1: High definition transcranial alternating current stimulation: Alternating current of 2 mA will be administered using a standard equipment starstim-32 for 20 minutes where electrodes wil

Sponsors

Central institute of psychiatry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: DIAGNOSIS OF SCHIZOPHRENIA USING ICD-10. SCHIZOPHRENIA ILLNESS DURATION MORE THAN 2 YEAR & ON STABLE DOSE OF ANTIPSYCHOTICS. MONTREAL COGNITIVE ASSESSMENT TEST SCORE 25 OR MORE. RIGHT HANDED PEOPLE. PATIENT GIVING WRITTEN INFORMED CONSENT.

Exclusion criteria

Exclusion criteria: PRECENCE OF CO-MORBID NEUROLOGICAL DISORDER. CLINICALLY DIAGNOSED INTELLECTUAL DISABILITY. PAST HISTORY OF SEIZURE EPISODE. PAST HISTORY OF SIGNIFICANT HEAD INJURY. PATIENT RECEIVED ECT IN LAST 6 MONTH. CALGARY DEPRESSION SCALE FOR SCHIZOPHRENIA SCORE MORE THAN 7. SIMPSON ANGUS SCALE SCORE MORE THAN 0.65.

Design outcomes

Primary

MeasureTime frame
Primary outcome of the study is changes in cognitive function in patients with schizophrenia as assessed by neuropsychological tests at baseline and at the completion of adjunctive online theta frequency tACS after 5 days.Timepoint: Assessed at baseline and at the completion of adjunctive HD-tACS after 5 days.

Secondary

MeasureTime frame
Secondary outcome is change in schizophrenic symptoms as measured by PANSS at baseline and after completion of adjunctive online theta frequency tACS after 5 days.Timepoint: Assessed at the baseline and at the completion of adjunctive HD-tACS after 5 days.

Countries

India

Contacts

Public ContactDr Alok Pratap

Central institute of psychiatry

dralokpratap@gmail.com7781803812

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026