Prevention of propofol pain

Prevention of pain on injection of propofol: A comparison of pre-treatment with 5-HT3 receptor antagonists: Granisetron, Ondansetron, Ramosetron - PGOR

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/11/038172

Enrollment

120

Registered

2021-11-22

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Propofol injection pain: Injection Ondansetron, Granisetron, Ramosetron Intervention2: ondansetron 4mg, IV: 5 HT3 receptor antagonist Intervention3: Placebo: Intravenous normal saline,

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 & 2, Planned to undergo general anaesthesia.

Exclusion criteria

Exclusion criteria: Cardiac problems, hypersensitivity to drugs, pregnancy, unstable hemodynamics

Design outcomes

Primary

Measure	Time frame
To compare pre-treatments with 5HT3 antagonists: Granisetron, Ondansetron,Ramosetron in reducing the incidence of Propofol injection pain in patients undergoing elective surgery under general anaesthesia.Timepoint: 0 to 20 seconds	—

Secondary

Measure	Time frame
The degree of pain due to propofol injection will be graded and recorded at 0, 5, 10, 15, 20 seconds respectively to assist in analyzing the severity of Propofol pain on injection.Timepoint: 0 to 20 seconds	—

Countries

India

Contacts

Public ContactShio Priye

Rajendra Institute of Medical Sciences

shiopriye@gmail.com09986743162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026