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Changes in arterial and end tidal carbon dioxide levels before and after fluid resuscitation in septic shock patients admitted in ICU

Arterial carbon dioxide and end-tidal carbon dioxide changes in pre and post volume resuscitation patients with septic shock admitted in Intensive Care Unit

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/11/038170
Enrollment
40
Registered
2021-11-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

None listed

Sponsors

PGIMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: all patients with age > 18 years admitted in intensive care unit with septic shock.

Exclusion criteria

Exclusion criteria: patients who refuse to participate in the study and patients having conditions affecting lung permeability like interstitial lung disease, idiopathic pulmonary fibrosis, severe bronchial asthma ,COPD, or cardiovascular conditions like congenital heart disease, valvular heart disease, cardiomyopathy having baseline LVEF < 30% , h/o pulmonary embolism, bronchopleural fistula, extracorporeal life support.

Design outcomes

Primary

MeasureTime frame
changes in arterial PCO2 and end- tidal carbon dioxide (EtCO2) pre and post resuscitation in septic shock patientsTimepoint: At 0 hour, 1 hour and 6 hours of resuscitation—

Secondary

MeasureTime frame
correlation between central venous-arterial PCO2 (â??PCO2) gap and arterial PCO2-EtCO2 (A-E) CO2 gap in all the patientsTimepoint: At 0 hour, 1 hour and 6 hours of resuscitation;correlation between these two gaps in critically ill septicemic patients in the context of extent of fluid requirement, extent of inotrope requirement, extent of organ damage (SOFA score) and ICU mortality Timepoint: at the time of admission and discharge/death—

Countries

India

Contacts

Public ContactDr Subrata Podder

PGIMER

podder_s@yahoo.co.in7087009526

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026