Health Condition 1: H04- Disorders of lacrimal system
Conditions
Interventions
Intervention1: Initiation of treatment with Retinol Palmitate in addition to standard treatment: Intervention: 1000IU of Trans-Retinol Palmitate in Hydrogenated Castor Oil in QID dosing in the interve
Sponsors
Dr Rajendra Prasad Centre for Ophthalmic Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients with severe dry eye and ocular surface keratinization in chronic Stevens-Johnson Syndrome Patients willing to give consent
Exclusion criteria
Exclusion criteria: Age Pregnancy Presence of other ocular co-morbidities Patients not willing to follow up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual acuity Anterior and posterior segment examination Tear film breakup time Schirmers test Tear film height (ASOCT) Epithelial Mapping on ASOCT (Rtvue) Impression cytology for conjunctival goblet cell density, conjunctival keratinization, corneal keratinization Tear film TGF beta and MMP-9Timepoint: Pre- treatment 1 week 2 weeks 4 weeks 8 weeks 12 weeks (Impression cytology for conjunctival goblet cell density, conjunctival keratinisation, corneal keratinisation; and Tear film TGF beta and MMP-9 will be performed pre treatment, 1 week, 4 weeks and 12 weeks only) | — |
Secondary
| Measure | Time frame |
|---|---|
| OSDI QuestionnaireTimepoint: Pre- treatment 1 week 2 weeks 4 weeks 8 weeks 12 weeks | — |
Countries
India
Contacts
Public ContactProf Rajesh Sinha
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, NEW DELHI
Outcome results
None listed