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Study to test a method of detecting lung complications after laparoscopic surgeries

Modified Lung Ultrasound Score (LUSS) in patients undergoing laparoscopic abdominal surgeries under general anesthesia with targeted driving pressures compared to conventional ventilation strategies - A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/038118
Enrollment
90
Registered
2021-11-18
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Modified ventilation strategy with targeted driving pressures: Initial ventilator settings: Tidal volume of 6 to 8 ml/kg Respiratory rate with target EtCO2 between 35 and 40 mm Hg FiO2

Sponsors

Intramural funding JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients between 18 and 75 years of age planned for laparoscopic abdominal surgeries under general anesthesia in Trendelenburg position 2) Duration of surgery more than 2 hours (from the time of creation of the pneumoperitoneum) like surgeries for prostate, rectum, total laparoscopic hysterectomy, etc. 3) Patients expected to be extubated on table post operatively

Exclusion criteria

Exclusion criteria: 1) Patients with history of acute respiratory distress syndrome 2) Pregnant patients 3) Patients with cardiac comorbidities of NYHA class III and IV 4) Patients with valvular heart diseases 5) Patients with history of stroke 6) Patients with elevated intracranial pressure 7) Previous lung surgery 8) Severe Chronic obstructive pulmonary disease (COPD) with Forced expiratory volume/Forced vital capacity (FEV1/FVC) 9) History of progressive neuromuscular illness 10) Refusal to participate

Design outcomes

Primary

MeasureTime frame
To compare modified Lung Ultrasound Score (LUSS) in patients undergoing laparoscopic abdominal surgeries under general anesthesia with targeted driving pressures and conventional ventilation strategiesTimepoint: Baseline (preoperative), 15 to 30 minutes after extubation—

Secondary

MeasureTime frame
1.To compare the differences in peak inspiratory pressure (PIP), plateau pressures, PEEP, Partial pressure of oxygen in arterial blood/Fraction of inspired oxygen (PaO2/FiO2) in patients undergoing laparoscopic abdominal surgeries under general anesthesia with intraoperative targeted driving pressures and conventional ventilation strategies 2. To compare the incidence of postoperative pulmonary complications (PPC) in patients undergoing laparoscopic abdominal surgeries under general anesthesia between the groups 3. To correlate the Lung ultrasound score to development of postoperative pulmonary complications 4. To compare the serum levels of Interleukin -6(IL-6), HS CRP, TNF- ? and IL-1ß in patients undergoing laparoscopic abdominal surgeries under general anesthesia with intraoperative targeted driving pressures and conventional ventilation strategiesTimepoint: Baseline(preoperative), 15 to 30 minutes after extubation, postop day 1—

Countries

India

Contacts

Public ContactDr Anusha cherian

JIPMER

anushacherian@gmail.com9789197801

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026