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comparing the effect two drugs, moxonidine and clonidine, on reducing pain and other properties of spinal nerve block

COMPARISON OF ORAL CLONIDINE AND MOXONIDINE ON SENSORY AND MOTOR CHARACTERISTICS OF SUBARACHNOID BLOCK

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/038087
Enrollment
60
Registered
2021-11-16
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K40-K46- Hernia Health Condition 2: S70-S79- Injuries to the hip and thigh Health Condition 3: S80-S89- Injuries to the knee and lower leg

Interventions

Intervention1: Tab Moxonidine: Tab moxonidine 400mcg 1 hour before surgery Control Intervention1: Moxonidine: Tab Moxonidine 0.4mg before subarachnoid block Control Intervention2: Clonidine: Tab cloni

Sponsors

Shreyas S Bhat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) Patients who are willing to give written informed consent b) Patients posted for infraumbilical surgeries. c) Age group- 18- 60 years, of either sex. d) American Society of Aneaesthesiologists (ASA) grade 1 and 2 e) Weight 50-80 kg. f) Height 150 cm to 180 cm.

Exclusion criteria

Exclusion criteria: Patients who are not willing to give informed written consent for study. b) Allergy to local anesthetics c) Uncontrolled diabetes mellitus, hypertension, cardiac disorders, neuropathies, patients with chronic analgesic use, psychiatric medications. d) Pregnancy. e) Contraindications/relative contraindications to spinal anaesthesia. Hypovolemic shock, Bleeding diathesis and coagulopathy

Design outcomes

Primary

MeasureTime frame
Onset of sensory blockade of subarchnoid block, 2 segment regression time, duration of analgesia postoperativelyTimepoint: Onset of sensory blockade checked every 2 minute till maximum level is acheived, 2 segment regression time, duration of analgesia is assesed 30 min, 1 hour, and then 2nd hourly for 24 hours

Secondary

MeasureTime frame
Motor characteristics of motor blockade, hemodynamic parameters.Timepoint: duration of motor blockade assesed every two minutes till max motor blockade,hemodynamics assesed every five minutes intraoperatively and every hour postoperatively for 24 hours.

Countries

India

Contacts

Public ContactShreyas S bhat

Bangalore medical college and research institute

drsudhi@rediffmail.com8277401785

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026