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Does Intravenous Lipid Emulsion reverse the effect of spinal anaesthesia in patients undergoing elective surgery?

Efficacy of Intravenous Lipid Emulsion as a reversal agent for subarachnoid block in patients undergoing elective surgery: An exploratory randomized double blinded controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/038080
Enrollment
60
Registered
2021-11-16
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N329- Bladder disorder, unspecified Health Condition 2: 4- Measurement and Monitoring

Interventions

Intervention1: INTRA VENOUS LIPID EMULSION: After confirming the level of blockade surgery will be started. At the end of surgery ,patient will be given study drug (ILE) at the dose of 1.5mg/kg for ov

Sponsors

AIIMS RISHIKESH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA-I & II physical status 2.Elective Surgery duration of up to 1 hour under subarachnoid block

Exclusion criteria

Exclusion criteria: 1. Patient refusal to participate 2. Coagulopathies 3. Infection or sepsis at the site of subarachnoid block 4. Allergic to local anesthetic drugs and intravenous lipid emulsion 5. Evidence of proven psychiatric illness 6. History of adverse outcomes in postop period after previous surgery 7. Presence of severe disabling diseases (ASA 4 and ASA 5 Grade)

Design outcomes

Primary

MeasureTime frame
1.Is there reversal of sensory and motor blockade of subarachnoid block after administering intravenous lipid emulsion (ILE) in patients undergoing elective surgery under spinal anesthesia or not. 2.Time duration of sensory and motor blockade of subarachnoid block after administering intravenous lipid emulsion in patients undergoing elective surgery under spinal anesthesia. Timepoint: Till 2 hour 30 minutes of immediate post operative period—

Secondary

MeasureTime frame
1.Complications if any after administering intralipids. 2.Pain scores 3.Time required to shift the patient from PACU to ward. Timepoint: 2 hours 30 minutes of immediate post operative period—

Countries

India

Contacts

Public ContactDrKarthikeyan

AIIMS,Rishikesh

praveenrt64@gmail.com9654162941

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026