Health Condition 1: E118- Type 2 diabetes mellitus with unspecified complications
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Manipal College of Dental Sciences Manipal
Department of Biochemistry
Eligibility
Inclusion criteria
Inclusion criteria: Healthy participants in the age group of 30-50 years, without a history of diabetes and participants with a history of Type 2 diabetes for not more than 3 years, will be recruited after their oral and written informed consent.
Exclusion criteria
Exclusion criteria: All participants with a history of type 1 diabetes, smoking (using tobacco products on recruitment to the study and those who quit smoking within the past year will be considered smokers), acute and major chronic inflammatory/immune disorders including autoimmune conditions, infections (including tuberculosis, HIV, hepatitis B, and hepatitis C), pulmonary, liver diseases and malignancies (within the last 5 years), treatment with medications known to affect periodontal status (phenytoin and cyclosporine antioxidant, vitamin or mineral supplements), any form of systemic or local immunosuppression (including steroids) within the previous 6 months, habit of chewing pan, supari, gutka, tobacco, areca nut, betel leaf, etc. will be excluded. Physically handicapped and mentally challenged individuals; Pregnant or lactating females and patients who had undergone any periodontal treatment in the previous six months will also be excluded from the study. Subjects with less than 10 functional teeth will be excluded. All participants will be recruited after their oral and written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantity and qualitative characterization of AGEs in the gingiva, GCF, serumTimepoint: baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome variables: b. Plaque index c. Gingival Index d. Total antioxidant capacity in GCF and Serum e. Age, Smoking status, Glycated Hemoglobin, lipid profile, BMI (height and weight)Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactAditi Chopra
Manipal College of Dental Sciences, Manipal
Outcome results
None listed