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Two groups of Drugs are compared to find out their efficacy in preventing Post operative Nausea and Vomiting.

Comparison of efficacy of intravenous Palonosetron versus Ondansetron and Dexamethasone for prevention of post operative nausea and vomiting (PONV) in patients undergoing Laparoscopic surgeries.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/037949
Enrollment
60
Registered
2021-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Ondansetron and Dexamethasone: Dexamethasone 0.1mg/kg IV single dose + Ondansetron 0.1mg/kg iv single dose Control Intervention1: Palonosetron: Palonosetron 0.075 mg IV single dose

Sponsors

Sree balaji medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients undergoing Laparoscopic surgeries at Sree Balaji Medical College and Hospital 1. Elective laproscopic surgeries 2. ASA grade - 1,2,3 3. Age between 15 and 60 years.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. ASA grade-4 3. Pregnant and lactating women. 4. Known case of hypersensitivity reaction to Palonosteron and Dexamethasone and Ondansetron. 5. Patients on steroid therapy,antiemetics, or on treatment with other medications known to produce nausea and vomiting. 6. Patients with history of motion sickness,nausea and vomiting pre operatively.

Design outcomes

Primary

MeasureTime frame
Expected outcome of this study is to find out the efficacy of two antiemetic drug regimens for PONV and the side effects of the respective drugs used is noted. Timepoint: Time points are at 2 hrs , 12 hrs and 24 hrs of post op—

Secondary

MeasureTime frame
to find out the incidence of adverse effects in the two drug regimensTimepoint: to find out the incidence of adverse effects in the two drug regimens for 24 hrs post operatively—

Countries

India

Contacts

Public ContactRICHARDS

sree balaji medical college

dr.vs.md@gmail.com8220266543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026