Health Condition 1: N04- Nephrotic syndrome
Conditions
Interventions
Intervention1: single dose prednisolone: children with first episode nephrotic syndrome in the intervention arm will be given prednisolone @2mg/kg/day as a single morning dose daily for 6 weeks
Contr
Sponsors
Institute of child health kolkata
Eligibility
Inclusion criteria
Inclusion criteria: All children between 1 to 12 years , with first episode steroid naïve nephrotic syndrome and being commenced on prednisolone were included in this study.
Exclusion criteria
Exclusion criteria: 1.Children with previous history of nephrotic syndrome 2.Children already on steroids. 3.Children with allergy to egg or egg components . 4.Children below 1yr and above 12yrs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of effect of single dose versus divided dose prednisolone on HPA axis at 6 weeks of treatment in children with first episode of nephrotic syndrome.Timepoint: 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Documentation of the time to remission [Remission: urine albumin nil or trace (or proteinuria 4 mg/m2/h) for 3 consecutive early morning specimens] 2. Documentation of number of relapses and the time to first relapse (if any) in the two study groups till 6 months after completion of steroid therapy. Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Tania khan
Institute of child Health,kolkata
Outcome results
None listed