Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Tab. Aprepitant 80mg: Tab. Aprepitant 80mg given to patients with small sips of water 3 hours prior to proposed surgery.
Control Intervention1: Inj. Ondansetron 4mg: Inj. Ondansetron 4m
Sponsors
JSS MEDICAL COLLEGE AND HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: Adults of ASA Physical status class I/II aged 18-60 years undergoing laparoscopic surgeries.
Exclusion criteria
Exclusion criteria: Patients already on treatment with anti-emetics, steroid medication, or any other drug known to cause emesis currently or in the immediate past Patients with known hypersensitivity to ondansetron or aprepitant Pregnant or nursing mothers. Hepatic, renal or cardiac insufficiency. Vomiting within 24 hours before surgery or of any organic aetiology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy between Ondansetron and Aprepitant for prevention of PONV in patients undergoing laparoscopic surgeries.Timepoint: To assess the efficacy of aprepitant following surgery with no incidence of PONV immediately after surgery, 2hours, 4hours, 6hours, 12hours and 24hours following surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To determine the safety of aprepitant as a part of antiemetic prophylaxis. 2) To determine the requirement of rescue antiemetics post-operatively. Timepoint: Post operative usage of rescue antiemetics and adverse events noted immediately following surgery, after 2 hours, 4 hours, 6 hours, 12 hours and 24 hours. | — |
Countries
India
Contacts
Public ContactDr Anil Kumar MR
JSS MEDICAL COLLEGE AND HOSPITAL
Outcome results
None listed