Effect of brain stimulation and speech-language therapy in the management of grammatical deficits in persons with post-stroke aphasia.

Effect of a morphosyntactic training program and anodal transcranial direct current stimulation in treating Kannada case markers in persons with post-stroke non-fluent aphasia.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/11/037878

Enrollment

Registered

2021-11-08

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G938- Other specified disorders of brain

Interventions

Intervention1: Morphosyntactic training program (MSTP) and transcranial direct current stimulation (tDCS): The effect of a morphosyntactic training program (MSTP) and transcranial direct current stimu

Eligibility

Inclusion criteria

Inclusion criteria: a) Diagnosis of left hemisphere cerebrovascular accident (CVA) by a medical practitioner and confirmed by CT/MRI scan b) Post-stroke onset at least > 6 months c) Rt handedness prior to stroke d) Individuals with non-fluent aphasia (NFA) diagnosed by an SLP using Western aphasia battery Kannada version e) Native speaker of Kannada with any dialectical variations f) Functionally adequate hearing, vision, and ability to follow instructions will be selected based on informal screening g) Persons with grammatical case marker deficits and word-level verbal output

Exclusion criteria

Exclusion criteria: a) Severe apraxia or dysarthria b) Contraindication to use tDCS conditions (e.g., history/complaint of seizures, migraine, or skin allergy, cranium metallic implants) c) Visual field neglect d) Use of any medications which will affect the cortical excitability (antidepressants, antiepileptic drugs, etc.) e) Current enrolment in SLT.

Design outcomes

Secondary

Measure	Time frame
a) Changes in the amplitude and latency of the P600 ERP component post treatment b) Change in the MLU, accuracy and frequency of usage of case markers in sentence production through analysis of speech samples. The response of the participants will be transcribed by the researcher and analysed for the frequency and accuracy of usage of case markersTimepoint: Pre-post intervention Follow up after one month of intervention	—

Measure

Time frame

a) Changes in the amplitude and latency of the P600 ERP component post treatment b) Change in the MLU, accuracy and frequency of usage of case markers in sentence production through analysis of speech samples. The response of the participants will be transcribed by the researcher and analysed for the frequency and accuracy of usage of case markersTimepoint: Pre-post intervention Follow up after one month of intervention

—

Primary

Measure	Time frame
Responses from the 100 pictures (50 each in Experimental probe A and Control probe A)Timepoint: Pre-post intervention Follow up after one month of intervention	—

Countries

India

Contacts

Public ContactDr Gopee Krishnan

Manipal Academy of Higher Education (MAHE)

krishnan.g@manipal.edu9036459815

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026