Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Control Intervention1: Capsule pregabalin: To check the effect of he drug for post operative analgesia when given preoperatively
Dose- 150 mg
Frequency- just once preoperatively
Route of administrati
Sponsors
Dr RIYA SHAH
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients posted for elective cardiac surgery using midline sternotomy incision under general anaesthesia 2. Both males and females 3. Age group between 18-65 years, 4. Patients weighing between 40 kg â?? 85 kg
Exclusion criteria
Exclusion criteria: 1. Patients with persistent nausea or vomiting at the time of randomization 2. Patients on mono amino oxidase inhibitors, tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors 3. Patients with Epilepsy, traumatic brain injury, stroke, transient ischemic attack, or brain tumor 4. Patients with opioid tolerance or opioid dependence 5. Patients having renal disease (creatinine >1.4 mg/dL) 6. Patients having liver disease (total bilirubin >1.5 mg/dL) 7. Patients having known allergies to any of the study drug 8. Patients having major psychiatric disorder 9. Pregnancy 10. Patients with left ventricular dysfunction (ejection fraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare following parameters in both the groups 1) Duration of analgesia 2) Haemodynamic parameters (heart rate & mean arterial pressure) 3) Adverse effect such as headache and nausea, vomiting 4) Sedation score. Timepoint: Post operatively 0,3,6,12,24 hourly | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare following parameters in both the groups 1) Total consumption of analgesic agents in the post operative period 2) Intra operative analgesic (Fentanyl) requirement Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactRIYA JAYANT SHAH
MGM MEDICAL COLLEGE AND HOSPITAL AURANGABAD
Outcome results
None listed