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Combined use of brain stimulation and cognitive training for treatment of Depression

Effectiveness of Transcranial Direct Current Stimulation (tDCS) combined with Digital Cognitive Emotional Training for treatment of Major Depression: a double-blind randomized sham-controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/037854
Enrollment
20
Registered
2021-11-08
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features

Interventions

Intervention1: Transcranial Direct Current Stimulation (tDCS) with Digital Cognitive Emotional Training: The participants will receive stimulation current at 2mA for 20 min with ramp up of 30 sec and

Sponsors

All India Institute of Medical Sciences New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. Between age 18-55 years 2. Either gender 3. Right-handed individuals 4. Patients fulfilling the Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM 5) criteria for the diagnosis of MDD 5. Patients scoring greater than 28 on MADRS 6. The patients who can at least read and write English/Hindi 7. Willing to give informed consent. 8. Drug free (medication naive) or not taking any psychotropic medications except hypnotics from previous two weeks.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Chronic medical or neurological illness (previously diagnosed) 2. Lifetime substance use disorder (excluding tobacco or caffeine) (as per DSM-5) 3. Suffering from or any psychiatric illness other than MDD 4. Not cooperative for testing 5. Past history of significant head injury 6. Known case of intellectual disability 7. Known or suspected pregnancy or currently lactating 8. Head metal implants 9. Subjects with significant suicidal risk upon clinical assessment 10. Any history of seizure 11. Previous history of receiving any brain surgical procedures 12. Electrical or magnetic stimulation on brain in the previous three months

Design outcomes

Primary

MeasureTime frame
Inter-group differences in change in scale scores (HAMD-17, MADRS and CGI).Timepoint: After 10 and 20 sessions—

Secondary

MeasureTime frame
Change in amplitude of event related potentials obtained in EEG for correlation to symptom improvementTimepoint: After 20 sessions—

Countries

India

Contacts

Public ContactRohit Verma

All India Institute of Medical Sciences

rohit.aiims@gmail.com09868005491

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026