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Mechanism of action of Yoga in alleviating DNA damage in Diabetes

NAD+-SIRT1 Axis: a key regulator for DNA repair and metabolic regulation following Yoga - YDD

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/037780
Enrollment
40
Registered
2021-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Yoga: Details of intervention: Name Posture Practices Breathing Exercise Standing Hand in out breathing Loosening practices (5min) Standing Hastauttanasana Padhastasana Ashvasanch
5 days/week for a total of 8 weeks (2 months
total of 40 hours of intervention) Details of intervention: Name Posture Practices Breathing Exercise Standing Hand in out breathing Loosening practices (5min) Standing Hastauttanasana Padhastasan

Sponsors

Swami Vivekananda Yoga Anusandhana Samsthana Deemed to be University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Type2DM UPTO 5 YEARS, HbA1c less than equal to 8%, BMI - 28-32 kG/m2, Blood Pressure less than equal to 140/90 mm/Hg

Exclusion criteria

Exclusion criteria: smokers, HbA1c more than 8%, any other existing diabetic comorbidity

Design outcomes

Primary

MeasureTime frame
The outcome of the proposed study shall hold answer to the mechanism adopted by Yoga practices in addressing DNA damage and promoting cell survival, genome integrity, insulin sensitivity in Diabetes and probably this finding can be extended to other metabolic disorders with Reactive Oxygen Species as a factor that induces complications. Primary Variable - DNA damage (comet assay)Timepoint: T0 and T2 (after 2 months of intervention)

Secondary

MeasureTime frame
Technique Assessments Psychology Perceived Stress Scale, Perseverative Thinking Questionnaire, Sleep quality questionnaire Western Blot Sirt1, PARP1, FOXO1, HDAC1, p53, NFkB, PGC1a, ATM, XPA, TDG, Ku70, Oxo8dG ELISA Insulin, IL-6, SOD, IL-10 RT-PCR SIRT1, PARP1, FOXO1, ATM genes Timepoint: T0 and T2 (after 2 months of intervention)

Countries

India

Contacts

Public ContactRamesh MN

swami vivekananda yoga anusandhana samsthana, deemed to be University

ramesh.mavathur@svyasa.edu.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026