Health Condition 1: - Health Condition 2: F317- Bipolar disorder, currently in remission
Conditions
Interventions
Intervention1: Structured Pranayama therapy will be given as adjunctive therapy to conventional treatment for patients with Bipolar I disorder: 2 months of structured Pranayama therapy will be given a
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed with Bipolar Disorder as per ICD-10 DCR (International Classification of Diseases 10th edition – Diagnostic Criteria for Research) Either gender Age between 18 to 45 years Presently in the euthymic state defined by the current Young Mania Rating Scale (YMRS) score of 7 or less and Hamilton Depression Rating Scale (HDRS) of 7 or less. On stable doses of mood stabilizers and/or antipsychotics for the last 6 weeks
Exclusion criteria
Exclusion criteria: Patients with comorbid alcohol, tobacco, cannabis or another drug dependence Patients with current active infections such as tuberculosis on active phase treatment or COVID-19 within the last 3 weeks Comorbid autoimmune diseases Pregnant and lactating women Pre-existing endocrine disorders Pre-existing chronic illness like diabetes, hypertension, hepatic and renal disease, connective tissue diseases, malignancies Individuals who are already practicing some form of structured pranayama or yoga on a regular basis will also be excluded from the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Improvement in Blood pressure Time-domain and frequency-domain indices of HRV HR and BP response to standing HR response to deep breathing BP response to isometric handgrip BRS Parameters - stroke volume, CO, TPRS, BRS value Serum levels of cortisol, hs-CRP, IL-4, BDNF, MDA levels Cognition- P300, Visual Reaction Time(VRT), Auditory Reaction Time(ART) Stress score (PSS) PSQI score, ESS score WHO-QoL BREF Positive and Negative Affect Schedule (Short from)- PANAS-SF score Compliance to Pranayama- yes/no (weekly %)Timepoint: 2 months of Pranayama therapy improves the secondary outcome variables | — |
Primary
| Measure | Time frame |
|---|---|
| Improvement in sympathovagal balance (LF/HF ratio) in Bipolar I disorder patients receiving Pranayama therapy and conventional treatment for 8 weeks in comparison to the patients receiving conventional treatment onlyTimepoint: Improvement in sympathovagal balance (LF/HF ratio) in Bipolar I disorder patients receiving Pranayama therapy and conventional treatment for 8 weeks in comparison to the patients receiving conventional treatment only | — |
Countries
India
Contacts
Public ContactDrKalavathyT
JIPMER
Outcome results
None listed