FindTrial
Sign In

COMPARISION OF PRE-INTUBATION LARYNGEAL SPRAY ON INCIDENCE AND SEVERITY OF POSTOPERATIVE SORE THROAT WITH KETAMINE, LIDOCAINE, DEXAMETHASONE IN ADULT PATIENTS UNDERGOING SURGERY UNDER GENERAL ENDOTRACHEAL ANAESTHESIA-A PROSPECTIVE RANDOMISED DOUBLE BLINDED STUDY.

COMPARISION OF PRE-INTUBATION LARYNGEAL SPRAY WITH KETAMINE,LIDOCAINE AND DEXAMETHASONE ON INCIDENCE AND SEVERITY OF POST-OPERATIVE SORE THROAT IN ADULT PATIENTS UNDERGOING SURGERY UNDER GENERAL ENDOTRACHEAL ANAESTHESIA - A PROSPECTIVE RANDOMISED DOUBLE BLINDED STUDY.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/037718
Enrollment
105
Registered
2021-11-01
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecified Health Condition 2: K352- Acute appendicitis with generalized peritonitis Health Condition 3: K810- Acute cholecystitis Health Condition 4: K800- Calculus of gallbladder with acutecholecystitis Health Condition 5: K801- Calculus of gallbladder with othercholecystitis Health Condition 6: K802- Calculus of gallbladder without cholecystitis Health Condition 7: K00-K95- Diseases of the digestive system Health Conditi

Interventions

Intervention1: Inj ketamine 25mg: After laryngoscopy upon visualisation of vocal cords 25mg (0.5ml) Ketamine spray (made to 2ml with normal saline) the test drug will be sprayed by using 25G Quinckeâ?

Sponsors

JSSAHER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - Age 18 â?? 60 years - Either sex - ASA Status I & II - Surgery in supine position under GA for up to or less than 2 hours - Mallampatti Grade I & II

Exclusion criteria

Exclusion criteria: - Patient using steroids or NSAIDS - Patients with Chronic obstructive pulmonary disorder, asthma, reactive airway disease - Patients with greater than 2 attempts of intubation - Pregnant patients - Recent Upper respiratory tract infection ( - Patients allergic to study drug - Patients requiring Nasogastric tube, throat pack - Oral and nasal surgeries - Patients and his/her legally accepted representatives not willing to provide their voluntary written informed consent for participation in the study - Patients with IHD/ Rhythm abnormalities.

Design outcomes

Primary

MeasureTime frame
â?¢To compare the effectiveness of ketamine lidocaine and dexamethasone as pre intubation laryngeal spray on incidence and severity of postoperative sore throat over 24hrs post-extubation in patients receiving general endotracheal anaesthesia.Timepoint: Starting from general anaesthesia till twenty four hours after completion of surgery—

Secondary

MeasureTime frame
â?¢Heamodynamic changes after laryngoscopy and intubation. â?¢Postoperative alterations in voice. â?¢Adverse effects of study drugs like Emergent Delerium.Timepoint: Starting from general anaesthesia till twenty four hours after completion of surgery—

Countries

India

Contacts

Public ContactDr VYSHNAVI S

JSSAHER

vyshgiri@gmail.com9880110022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026