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Effect of an experimental drug in two different dose combination versus control drug alone for insertion of radial artery cannula using ultrasound

Effect of combination of subcutaneous lignocaine with two different doses of nitroglycerin versus subcutaneous lignocaine alone for ultrasound guided radial artery cannulation: A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/11/037704
Enrollment
168
Registered
2021-11-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection of subcutaneous lignocaine with subcutaneous Nitroglycerin 250 microgram: Injection of subcutaneous lignocaine 1% with subcutaneous Nitroglycerin 250 microgram in 0.5 ml (tota

Sponsors

All India Institute of Medical Sciences Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients admitted in Intensive Care Unit (ICU) or undergoing elective surgeries in Operating room at AIIMS Patna requiring radial artery cannulation.

Exclusion criteria

Exclusion criteria: Infection overlying the site, Absent pulse/poor circulation assessed by the modified Allen’s test, Coagulopathy, Partial/full thickness burn, Vascular graft in upper extremity, any vascular disease.

Design outcomes

Primary

MeasureTime frame
To estimate the first-attempt success rate of radial artery cannulation.Timepoint: 5 minutes—

Secondary

MeasureTime frame
To compare the diameter & cross sectional area of radial artery before and after subcutaneous administration of drugs.Timepoint: 5 minutes;To compare the mean number of attempts of radial artery cannulation. Timepoint: 5 minutes;To estimate the overall success rate of radial artery cannulation.Timepoint: 5 minutes;To estimate the percentage of patients developing puncture site hematoma.Timepoint: 5 minutes—

Countries

India

Contacts

Public ContactSaras Singh

All India Institute of Medical Science Patna

drraj76pmch@gmail.com9788859989

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026