Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
None listed
Sponsors
Maulana Azad Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Cofirmed COVID-19 cases (Positive for SARS-COV-2 by RT-PCR or rapid antigen test)
Exclusion criteria
Exclusion criteria: 1. Patients with a pre-existing autoimmune rheumatic disease. 2. Patients with a first degree relative (parents, children, siblings) who have autoimmune rheumatic disease. 3. Patients above 65 years of age. 4. Patients with HBV, HCV, HIV, tuberculosis (Active or past), leprosy, infective endocarditis, dengue, malaria, CLD/liver cirrhosis, malignancy and sarcoidosis. 5. Patients taking drugs known to induce formation of ANA. 6. Patient from another state. (Non- Delhite).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Proportion of COVID-19 patients having musculoskeletal and rheumatologic manifestations at admission, at 4 weeks and 12 weeks after discharge. 2. Proportion of COVID-19 patients having serum autoantibodies (RF, Anti CCP,ANA) at admission and 12 weeks after discharge.Timepoint: At the end of study | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of musculoskeletal and rheumatologic manifestations with clinical severity of COVID-19 and inflammatory markers viz. CRP, Ferritin, LDH, and IL-6. Timepoint: At the end of the study;Correlation of musculoskeletal and rheumatologic manifestations with presence and titres of serum autoantibodies viz. RF, Anti-CCP, and ANA.Timepoint: At the end of the study;Correlation of serum autoantibodies (RF, Anti-CCP and ANA) with clinical severity of COVID-19 and inflammatory markers viz. CRP, Ferritin, LDH, and IL-6.Timepoint: At the end of the study. | — |
Countries
India
Contacts
Public ContactDeepak Ranjan Malla
Maulana Azad Medical College, New Delhi
Outcome results
None listed