Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: Single bolus dose of dexmedetomidine 0.5mcg/kg i.v. diluted in 100ml of NS given over a duration of 10 minutes starting half hour prior to expected time of extubation e
Sponsors
Ramaiah Medical College
Eligibility
Inclusion criteria
Inclusion criteria: ASA 1 and 2 patients aged between 18 and 60 years scheduled to undergo elective surgery under general anaesthesia with endotracheal intubation.
Exclusion criteria
Exclusion criteria: 1. Presence of an upper or lower respiratory tract infection. 2. Anticipated difficult airway. 3. Hepatic or renal dysfunction. 4. Poorly controlled hypertension. 5. Surgeries involving the upper airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess and grade the severity of cough response at the time of extubation.Timepoint: During anesthetic emergence from surgery. Half hour after administering the test and control agents on the day of intervention only. no long term follow up planned | — |
Secondary
| Measure | Time frame |
|---|---|
| To study: a) Hemodynamic response namely heart rate, systolic blood pressures, diastolic blood pressures and mean arterial pressures at the time of extubation. b) Adverse events i.e. desaturation (spo292%), breath holding spells (apnoea15 seconds), laryngospasm, postoperative nausea and vomiting (PONV) at the time of extubation. c) Post-operative sedation.Timepoint: T0- basal parameters before anaesthetic induction; T1- before extubation; T2- after extubation; T3- 5 minutes after extubation. outcome is assessed on day of intervention only. no long term follow up is planned | — |
Countries
India
Contacts
Public ContactBhavish S
Ramaiah Medical College
Outcome results
None listed