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Use of two drug single or combination for prevention of nausea vomiting in caesarean

Phenylepherine, ondensetron or a combination of both for prevention of intraoperative nausea and vomiting in patients undergoing lower segment caesarean section :a prospective ,double blind randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037589
Enrollment
195
Registered
2021-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O80- Encounter for full-term uncomplicated delivery

Interventions

Intervention1: phenylepherine with bolus injection ondensetron: Patients will receive a prophylactic solution of 100microgm/ml of phenylepherine @15ml/hour (Dose 25microgm/min) with bolus injection on

Sponsors

DEPARTMENT OF ANESTHESIA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: This study will be carried out in term pregnant female patients with singleton pregnancy, taken up for elective Caesarean Section under spinal anaesthesia for various indications like previous Caesarean Section, breech presentation, cephalopelvic disproportion, pregnancy following infertility treatment, cord around neck, non progression of labour

Exclusion criteria

Exclusion criteria: 1.Patient refusal to participate in study 2.Emergency indication of Caesarean Section like antepartum haemorrhage, Placenta previa, abruptio placenta, fetal distress, obstructed labour, umbilical cord prolapse, preeclampsia, gestational diabetes, essential hypertension, more than two previous LSCS, history of PPH, multiple gestation. 3.Patients having contraindication for subarchnoid block. 4.Patient having associated systemic illness (hypo/hyperthyroidism, diabetic, neuromuscular disease ischemic/ valvular/ congenital heart disease, psychiatric, hematological disorder, SLE). 5.History of seizures, coma, neurological signs or symptoms (Eclampsia) 6.Any allergy to local anaesthetic or any drug. H/o PONV

Design outcomes

Secondary

MeasureTime frame
Nausea score Total consumption of phenylepherine in intraoperative periodTimepoint: intraoperative

Primary

MeasureTime frame
Incidence of IONVTimepoint: intraoperative

Countries

India

Contacts

Public ContactPRATIBHA

Rnt medical college

vbedimd@gmail.com9829025373

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026