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Use of Nuclear magnetic resonance to study metabolic effluent from coronary sinus by two different cardioplegia and there effect on post cardiopulmonary bypass myocardial function.

Changes in Metabolic Effluents from coronary sinus as assessed by NMR: Comparison between St Thomas and Del Nido Cardioplegia solution along with their effect on Post CPB myocardial function.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037570
Enrollment
20
Registered
2021-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves

Interventions

Intervention1: Sample: Blood sample will be drawn from cardio pulmonary bypass reservior and from the coronary sinus in the right atrium.

Sponsors

Research Cell SGPGI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 20 patient, patients will be randomly allocated between two ARMs (10+10) [i.e., St Thomas group (ST) and Delnido group (DN), age 18- 65 years, informed consent. All Patients posted for trans-septal mitral valve replacement will be randomized to receive cardioplegia.

Exclusion criteria

Exclusion criteria: any history of ischemic heart disease or recent heart failure, severe pulmonary hypertension, deranged coagulation profile and recent heart failure

Design outcomes

Primary

MeasureTime frame
assessment of relevant venous metabolic effluent from CS and there ratios from both cardioplegia solutions using NMR. Timepoint: It will be giving before and after giving cardioplegia and ratio of metabolic effluents will be compared in between the two solutions.—

Secondary

MeasureTime frame
effect of these two cardioplegia on myocardial function post CPB and its corelation with metabolites along with patient outcome ( ICU stay and hospital discharge) Timepoint: effect of these two cardioplegia on myocardial function post CPB and its corelation with metabolites along with patient outcome ( ICU stay and hospital discharge)—

Countries

India

Contacts

Public ContactAmit Rastogi

SGPGI, Lucknow

amit.rastogi.sgpgi@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026