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COMPARISON OF CHANGES IN BRAIN OXYGENATION BETWEEN TWO CARBON DIOXIDE LEVELS USING TWO ANAESTHETICS

A COMPARISON OF THE EFFECT OF ANAESTHESIA WITH SEVOFLURANE AND PROPOFOL ON CEREBRAL OXYGENNATION DURING HYPERVENTILATION IN PATIENTS UNDERGOING SUPRATENTORIAL TUMOUR EXCISION â?? A RANDOMISED CONTROL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037506
Enrollment
50
Registered
2021-10-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C711- Malignant neoplasm of frontal lobe

Interventions

Intervention1: Hyperventilation: Patient is hyperventilated to a PaCO2 of 30mmHg. cerebral oxygenation at a PaCO2 of 30mmHg is noted Control Intervention1: Normocarbia: We aim to compare the effect of

Sponsors

Sree Chitra Tirunal Institute for Medical Sciences and Technology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Consenting adult patients undergoing elective supratentorial tumour excision 2.Age 18-60yrs 3.ASA (American Society of Anaesthesiologists) class 1 and 2 4.GCS 15 prior to the surgery

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Age 60yrs 3.Patients with a difference of 10% or more in the baseline NIRS values between right and left sides 4.Patients with clinical signs (headache, vomiting, confusion, papilloedema, pupillary asymmetry) or radiological signs (midline shift >1cm, presence of hydrocephalus) of raised intracranial pressure preoperatively 5.Patients with carotid artery disease 6.Long standing uncontrolled diabetes mellitus, systemic hypertension, cardiovascular disease, COPD 7.Patients with previous history of stroke, transient ischemic attacks 8.Obesity 9.ASA class III, IV, V patients. 10.Patients with subarachnoid hemorrhage, vasospasm. 11.Pregnant & nursing mothers.

Design outcomes

Primary

MeasureTime frame
comparison of cerebral oxygenation between sevoflurane and propofol anaesthesia in patients undergoing supratentorial tumour excisionTimepoint: at a steady state of PaCO2 of 36-38mmHg—

Secondary

MeasureTime frame
comparison of cerebral oxygenation at normocarbia and during hyperventilation in patients undergoing supratentorial tumour excisionTimepoint: at 20minutes of normocarbia at 20minutes of hyperventilation—

Countries

India

Contacts

Public ContactSALINI R VARMA

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

smita_vimala@yahoo.com9497324725

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026