Health Condition 1: - Health Condition 2: - Health Condition 3: - Health Condition 4: O- Medical and Surgical
Conditions
Interventions
Intervention1: neuromuscular blocking agent and monitoring: We will compare the efficacy and safety of neuromuscular blocker, rocuronium versus atracurium for elective surgeries lasting for half an ho
Sponsors
Adesh Institute of Medical Sciences and Reaesrch
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 1- 12 yrs of both the sexes, undergoing elective surgeries of average duration half to two hours, under general anaesthesia with ASA grade I-II and Mallampati class I&II will be included in the study.
Exclusion criteria
Exclusion criteria: 1. Patients refusing to give informed consent. 2. Patients having major cardiovascular, pulmonary, hepatic, renal and neuromuscular diseases. 3. Allergic to any study drug. 4. Patients taking medications which interfere with NMBs - calcium channel blockers, B-blockers, steroids, anticonvulsants, frusemide, polypeptide antibiotics or aminoglycosides 5. Those with diseases affecting neuromuscular transmission (myopathies) or family history of neuromuscular disease. 6. Overweight patients. 7. Children coming for emergency operations. 8. Patients with anticipated difficult intubation (Mallampati score III and more).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare the onset of action of the NMB between the two groups. We will compare the intubating conditions and intubation time of the two groups. We will also evaluate extubation time and recovery between the two groups. We will monitor and compare the hemodynamic changes and complications between the two groups. Timepoint: Hemodynamic variables are monitored before induction (baseline), after induction, after injection of NMB and before endotracheal intubation, just after intubation and then every 5 minutes for 30min after intubation, then every 15 mintutes afterwards till extubation and complete recovery Calibration of the relaxogram will be performed using supramaximal stimulation delivered in train-of-four (TOF) every 20 seconds (starts from induction of anesthesia till extubation of patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the efficacy and safety of neuromuscular blocker, rocuronium versus atracurium at a dose 2 x (ED95) for elective surgeries under general anaesthesia in paediatric patientsTimepoint: Hemodynamic variables are monitored before induction (baseline), after induction, after injection of NMB and before endotracheal intubation, just after intubation and then every 5 minutes for 30min after intubation, then every 15 mintutes afterwards till extubation and complete recovery Calibration of the relaxogram will be performed using supramaximal stimulation delivered in train-of-four (TOF) every 20 seconds (starts from induction of anesthesia till extubation of patient. | — |
Countries
India
Contacts
Public ContactDr Shilpa Bansal
Adesh Institute of Medical Sciences and Research
Outcome results
None listed