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Evaluating the effectiveness of different dental irrigating solution combinations (i.e, Sodium Hypochlorite with EDTA, Etidronate and Chitosan) when used along with ultrasonic activation on reduction of the bacterial load and post-treatment pain - a randomized controlled trial.

The Effect of Passsive Ultrasonic Activation with Different Irrigating solutions on the Reduction of Microbial load and Postoperative Pain in Root canals with Necrotic pulp - A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037484
Enrollment
60
Registered
2021-10-22
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Group 2: 3% NaOCl + Etidronate + Passive Ultrasonic Activation Intervention2: Group 3: 3% NaOCl + 0.2% Chitosan + Passive Ultrasonic Activation Control Intervention1: Group 1: 3% NaOCl

Sponsors

Karthikeyan Anbalagan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients whose teeth have pulp necrosis, which will be confirmed by absence of a response to pulp sensitivity tests and radiographic evidence of apical periodontitis or periapical radiolucency. 2. No spontaneous pre-treatment pain or at the time of the appointment.

Exclusion criteria

Exclusion criteria: 1. Patients who used antibiotics in the past three months or had systemic disease. 2. Visibly exposed root canals. 3. Teeth that could not be isolated. 4. Fistula and oedema in periapical tissues. 5. Advanced periodontal disease. 6. Incomplete root formation. 7. History of recent dental trauma. 8. Teeth with root canal curvatures greater than 20°. 9. Teeth shorter than 15mm and longer than 25mm. 10. Crown/root fracture, root resorption or calcifications.

Design outcomes

Primary

MeasureTime frame
Reduction of Microbial Load Timepoint: 6 months

Secondary

MeasureTime frame
Post-Operative painTimepoint: At 8hrs, 24hrs, 48hrs and 7days following root canal treatment

Countries

India

Contacts

Public ContactKarthikeyan Anbalagan

S.C.B Dental College and Hospital

amitjena@yahoo.com9437836499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026