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Role of subconjunctival injection of Bevacizumab (Anti VEGF) for Corneal Neovascularisation,after cornea Transplant

Subconjunctival injection of Bevacizumab (Anti VEGF) for Corneal Neovascularisation,after Penetrating Keratoplasty, A Prospective,Open Label,Non Comparative study

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037416
Enrollment
50
Registered
2021-10-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: H598- Other intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified

Interventions

Intervention1: Subconjunctival injection of Bevacizumab: Subconjunctival injection of Bevacizumab 2.5 mg/0.1 ml ,3 doses at an interval of one month each . Control Intervention1: NOT APPLICABLE: NOT A

Sponsors

SNMedical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)patients having 2 or more than 2 quadrant corneal neovascularisation 2)patients who developed corneal neovascularisation during F/U ,not responding to conventional medical treatment . 3)patients who gave consent to be in follow up.

Exclusion criteria

Exclusion criteria: 1)patients having persistent epithelial defect 2)patients who were systemically not fit for subconj Bevacizumab injection;pts with H/O recent attack of M.I.,stroke and uncontrolled Hypertension. 3)pregnant female

Design outcomes

Primary

MeasureTime frame
Corneal Neovascularization ParametersTimepoint: Follow up at an interval of one month after first dose of subconjunctival Bevacizumab till the completion of study period

Secondary

MeasureTime frame
Graft clarity,CCT and visual acuityTimepoint: Follow up at an interval of one month after first dose of subconjunctival Bevacizumab till the completion of study period

Countries

India

Contacts

Public ContactDr Shefali Mazumdar

S.N.MedicalCollege Agra

shefalimazumdar@gmail.com9457288925

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026