Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
None listed
Sponsors
Department of Bio Technology
Eligibility
Inclusion criteria
Inclusion criteria: -Willing to participate and provide blood and saliva samples at stipulated time points -Healthy Controls: No history of COVID-19, not vaccinated, negative for anti-SARS-CoV2 nucleoprotein antibodies -Asymptomatic / symptomatic participants: NPS-positive by RT-PCR; disease severity graded as per NIH guidelines
Exclusion criteria
Exclusion criteria: -Critically ill participants who cannot give informed consent -Those who are not willing to get an oral examination done -Those who cannot chew / drool to provide a SWMF sample due to severe/critical conditions -Participants with known malignancies and pregnancies -Participants who are on long-term immunosuppressants like those with autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mucosal immunity, as reflected in the oral cavity/oropharynx and the oral microbiome play a critical role in susceptibility and severity of COVID-19Timepoint: Day 0, 10-14, 30, 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| mucosal immunity and the oral microbiome explains differences in mortality between similar populationsTimepoint: Day 0, 10-14, 30 and 90 | — |
Countries
India, United Kingdom
Contacts
Public ContactDrNKumarasamy
VHS Infectious Diseases Medical Centre
Outcome results
None listed