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Comparison between morphine and nalbuphine as intrathecal adjuvants to 0.5% hyperbaric bupivacaine for subarachnoid block in lower abdominal surgeries.

Comparative evaluation of morphine versus nalbuphine as intrathecal adjuvants to 0.5% hyperbaric bupivacaine for subarachnoid block in lower abdominal surgeries: a prospective randomized double blind study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037339
Enrollment
60
Registered
2021-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N800- Endometriosis of uterus Health Condition 2: N433- Hydrocele, unspecified Health Condition 3: C569- Malignant neoplasm of unspecifiedovary Health Condition 4: K37- Unspecified appendicitis

Interventions

Intervention1: Intrathecal injection of 3ml 0.5 percent hyperbaric bupivacaine with 100 mcg morphine vs 400 mcg nalbuphine for sub arachnoid block lower abdominal abdominal surgeries: Subarachnoid Blo

Sponsors

MAHATMA GANDHI MEDICAL COLLEGE AND HOSPITAL JAIPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA) I and II patients Age group of 18-60 years Patient with written valid consent Patient undergoing elective lower abdominal surgery.

Exclusion criteria

Exclusion criteria: Patient refusal History of allergy to study drug Morbid obesity. Failure of spinal blockade. Bleeding disorders. Infection at the site. Anatomic abnormalities Inability to comprehend or participate in pain scoring system.

Design outcomes

Primary

MeasureTime frame
To assess and compare the analgesic efficacy of morphine with nalbuphine To assess and compare time of onset of sensory block Onset of complete motor blockade Duration of motor block To note and compare requirement of supplemental analgesic during surgery To compare intraoperative hemodynamic parameters Timepoint: 24 hours—

Secondary

MeasureTime frame
To assess and compare postoperative visual analogue scale (VAS) score at rest and with movement . Time to request for first rescue analgesia in both the groups. Total dose of rescue analgesia required in first 24 hrs. Incidence of side effects Timepoint: 24 hours—

Countries

India

Contacts

Public ContactDR DURGA JETHAVA

MAHATMA GANDHI MEDICAL COLLEGE AND HOSPITAL , JAIPUR

goyalvigya@gmail.com8349249511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026