COMPARING 2 LOCAL ANESTHETIC DRUGS WITH VARIABLE CONTENTS ON EFFECT OF NERVE BLOCKING

A COMPARATIVE EVALUATION OF THE EFFICACY OF LIGNOCAINE WITH ADRENALINE V/S LIGNOCAINE WITH ADRENALINE AND MAGNESIUM SULFATE FOR INFERIOR ALVEOLAR NERVE BLOCK- A RANDOMIZED CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/10/037284

Enrollment

Registered

2021-10-12

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin Health Condition 2: K052- Aggressive periodontitis Health Condition 3: K053- Chronic periodontitis Health Condition 4: K046- Periapical abscess with sinus Health Condition 5: K047- Periapical abscess without sinus

Interventions

Intervention1: MAGNESIUM SULPHATE 50%: MAGNESIUM SULPHATE HEPTAHYDRATE 50% (5ML/10ML) FOR IM /IV USE CONTAINING 4.06 MEQ MG++/ML, AROUND 0.3 ML OF 50% MGSO4 TO BE MIXED WITH 1.5ML OF LOCAL ANESTHETIC

Eligibility

Inclusion criteria

Inclusion criteria: 1)HEALTHY PATIENTS BETWEEN THE AGE GROUPS OF 18-60 YEARS DIAGNOSED WITH END STAGE DENTAL DISEASE REQUIRING EXTRACTION IN MANDIBULAR MOLAR REGION. 2)PATIENTS CLASSIFIED UNDER ASA 1 OR 2 3)SURGICAL PROCEDURES DONE UNDER CLASSICAL INFERIOR ALVEOLAR NERVE BLOCK 4)PATIENTS WHO CAN COMPREHEND THE PAIN SCALE USED IN THE STUDY

Exclusion criteria

Exclusion criteria: 1)PATIENTS UNDER ASA 3 OR GREATER. 2) PATIENTS ON ANTIDEPRESSANTS, ANTICOAGULANTS,CARDIAC GLYCOSIDES AND UNDER THE INFLUENCE OF ALCOHOL 3) PREGNANT OR LACTATING WOMEN 4) PATIENTS WHO ARE ALLERGIC TO COMPONENTS OF LOCAL ANESTHETIC OR MAGNESIUM SULPHATE

Design outcomes

Primary

Measure	Time frame
1) ONSET OF ANESTHESIA 2) EFFICACY 3) DURATION OF ANESTHESIA 4) DURATION OF ANALGESIA 5) POST OPERATIVE ANALGESIC EFFECT 6) POST OPERATIVE ANALGESIC REQUIREMENT Timepoint: 1) ONSET OF ANESTHESIA EVALUATED EVERY 30 SECONDS 2) DURATION OF ANESTHESIA EVALUATE EVERY 3O MINUTES 3) DURATION OF ANALGESIA FROM ONSET TILL PATIENT FEELS PAIN 5) POST OPERATIVE PAIN EVALUATED AT 24,48 HOURS USING HP VAS SCALE	—

Measure

Time frame

1) ONSET OF ANESTHESIA 2) EFFICACY 3) DURATION OF ANESTHESIA 4) DURATION OF ANALGESIA 5) POST OPERATIVE ANALGESIC EFFECT 6) POST OPERATIVE ANALGESIC REQUIREMENT Timepoint: 1) ONSET OF ANESTHESIA EVALUATED EVERY 30 SECONDS 2) DURATION OF ANESTHESIA EVALUATE EVERY 3O MINUTES 3) DURATION OF ANALGESIA FROM ONSET TILL PATIENT FEELS PAIN 5) POST OPERATIVE PAIN EVALUATED AT 24,48 HOURS USING HP VAS SCALE

—

Secondary

Measure	Time frame
1)Duration of Analgesia 2)Post operative analgesic effect 3)post operative analgesic requirementTimepoint: 1)Duration of analgesia: from the onset to till the moment patient feels pain for first time after anesthetic wears off 2)post operative analgesic effect : at 24,48 hours using HP VAS scale 3) postoperative analgesic requirement: nil	—

Countries

India

Contacts

Public ContactDR ROHIT S

RAJARAJESWARI DENTAL COLLEGE AND HOSPITAL

GHOUSE122@GMAIL.COM6366028931

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026