To compare the effect of ondansetron and granisetron on spinal anaesthesia induced decreased BP and decreased HR in elderly patients

Comparison of intravenous ondansetron with granisetron for spinal anaesthesia induced hemodynamic changes in elderly patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/10/037135

Enrollment

120

Registered

2021-10-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Spinal anaesthesia: Spinal anaesthesia will be given to elderly patients undergoing infraumbilical surgeries Control Intervention1: Ondansetron with granisetron: Effect of ondansetron a

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective surgeries under spinal anaesthesia aged between 50-70years of either gender, giving valid informed and written consent , belong to ASA grade 1 and 2

Exclusion criteria

Exclusion criteria: Patients with any contraindication to spinal anaesthesia . Patients with any history of anaphylaxis to local anaesthetics and allergy to study drugs. Obese patients with BMI >30kg/m2. Patients with coronary artery disease, MI, valvular heart disease, hypertension and DM. Patients having history of psychiatric illness or substance abuse or chronic alcoholic. Patients taking antihypertensive medications.

Design outcomes

Primary

Measure	Time frame
To study the effect of ondansetron in prevention of hypotension and bradycardia after spinal anaesthesia To study the effect of granisetron in prevention of hypotension and bradycardia after spinal anaesthesia To study the effect of normal saline in prevention on hypotension and bradycardia after spinal anaesthesia To compare the above 3 outcomesTimepoint: 2hours post-operatively	—

Secondary

Measure	Time frame
To compare the effect of ondansetron with granisetron in prevention of hypotension and bradycardia in patients undergoing spinal anaesthesiaTimepoint: 2hours postoperatively	—

Countries

India

Contacts

Public ContactDr Sarvjeet kaur

GGSMCH faridkot

drsarvjeetk@gmail.com9915680508

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026