Health Condition 1: J99- Respiratory disorders in diseasesclassified elsewhere
Conditions
Interventions
Intervention1: Tranexamic acid 500mg(5ml) nebulised to the patient 8th hourly till haemoptysis subsides.: Control of nonmassive haemoptysis in adult patients in emergency department with nebulised Tra
Sponsors
Vasudha D
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients more than 18 years of age, attending the emergency medicine department with nonmassive haemoptysis.(haemoptysis less than 200ml/day with no haemodynamic instability. Patients with more than one episode of haemoptysis (spitting of blood)in the last 24 hours.
Exclusion criteria
Exclusion criteria: 1. Massive haemoptysis( >200ml in the last 24 hours)with haemodynamic instability and/or respiratory obstruction, 2. Patients with haematemesis. 3. Patients on antiplatelet drug therapy, 4. Patients with pre-existing coagulation abnormalities, 5. Known hypersensitivity to the study drug, 6. Impaired renal functions (as evidenced by serum creatinine level more than 3mg/dl or need for renal replacement therapy), 7. Impaired hepatic function(serum bilirubin more than 2mg/dl,aspartate amino transferase greater than 3 times the normal,INR greater than 2).In case of subjects already started on treatment ,whose renal and hepatic function tests as detected by investigations above are impaired, they will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Among the patients undergoing treatment for hemoptysis, to compare the efficacy of nebulised TXA to that of intravenous TXA in 1. successful cessation of bleeding at 8 hours post administration, 2. amount of blood lost by expectoration per day 3. total dose of TXA administered for treatment success. Timepoint: Initial 8 hours and 8th hourly in the next 72 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications, duration of hospital stay,need for invasive procedures, number of transfusions,to assess for relapse in bleeding,as assessed by increasing episodes of haemoptysis,fall in Hb level to below 10g/dl or falls more than 2g/dl from the baseline value.Timepoint: Initial 8 hours and 8th hourly in the next 72 hours. | — |
Countries
India
Contacts
Public ContactVasudha D
JIPMER Puducherry
Outcome results
None listed