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Comparison between Clonidine and Lignocaine in response to laryngoscopy and endotracheal intubation

Comparative study between intravenous Clonidine and intravenous Lignocaine in the attenuation of pressor responses to laryngoscopy and endotracheal intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/10/037063
Enrollment
70
Registered
2021-10-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Control Intervention1: Intravenous Clonidine: Intravenous Clonidine 2mcg/kg over 10 min in attenuation of pressor responses in laryngoscopy and endotracheal intubation Control Intervention2: Intraven

Sponsors

Dr Shahbaz Haroon
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18-60 yr of either sex. 2. ASA grade I and grade II. 3. Patients posted for elective surgeries under general anesthesia requiring intubation. 4. Hemodynamically stable patients having all routine investigations within normal limits. 5. Patients who give written informed consent and are willing to be part of the study.

Exclusion criteria

Exclusion criteria: 1. Patients refusal. 2. Patients with ASA physical status III and more. 3. Patients with any pre-existing cardiovascular disease. 4. Patients with h/o allergy to test drugs. 5. Patients posted for emergency surgeries. 6. Patients with difficult airway. 7. Patients with neurological disorders and muscle diseases.

Design outcomes

Primary

MeasureTime frame
To observe the attenuation of pressor responses to laryngoscopy and endotracheal intubation with intravenous clonidineTimepoint: PRE INTUBATION, SCOPY 0 MINS, EVERY 5 MINUTES, UPTO 2 HOURS INTRA-OP, POST OP VAS, SEDATION—

Secondary

MeasureTime frame
To study the side effects of Clonidine and Lignocaine, if any and Ramsay sedation scaleTimepoint: Ramsay sedation scale: immediately, 1 hour, 6 hour and 12 hour after surgery—

Countries

India

Contacts

Public ContactDr Shahbaz Haroon

Dr. D. Y. Patil Medical College, Hospital & Research Centre

smitajoshi6@rediffmail.com9822053792

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026