Health Condition 1: K566- Other and unspecified intestinal obstruction
Conditions
Interventions
Intervention1: ISB (Isotonic Sodium Bicarbonate Group): Patients will receive 2 ml/kg/hr 1.3% Isotonic bicarbonate as maintenance fluid during the intraoperative period.
Control Intervention1: BSS (Ba
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age group 18-60yrs 2.Diagnosed case of perforation peritonitis requiring emergency laparotomy surgery
Exclusion criteria
Exclusion criteria: 1. Patient refusal 2. Inability to give informed consent 3. Pre-existing CKD on dialysis 4. Patients who are on oral bicarbonate therapy or have received bicarbonate in the last 24 hours 5. Critically ill patient with profound hemodynamic Instability requiring more than one vasopressor support 6. Patient with severe acidosis (Ph less than 7.0) 7. Pre-existing Alkalosis Ph more than 7.45 or HCO3 more than 26 mEq/L 8. Uncontrolled Diabetes Mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the difference in base excess (BE) between the patients receiving isotonic sodium bicarbonate or Ringer lactate at the end of surgeryTimepoint: At baseline,every hour during surgery, at the end of surgery, 1,6,24 and 72 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare between the two groups: 1.The pH, pCO2, Anion Gap, Lactate and blood sugars at baseline, every hour during surgery, at the end of the surgery, 1hour,12 hours and 24 hours after surgery 2. Duration of mechanical ventilation in the postoperative period 3. Incidence of re-exploration 4. Incidence of AKI within 7 days by KDIGO guidelines 5. Need of vasopressors in the perioperative period. 6. Duration of ICU and hospital stay 7. In-hospital mortality Timepoint: From the start of surgery till the discharge from hospital | — |
Countries
India
Contacts
Public ContactAjay Singh
Post Graduate Institute of Medical Education & Research, Chandigarh, India
Outcome results
None listed