Use of transcranial direct current stimulation in patients with alcohol dependence syndrome

Effect of adjunctive prefronto-cerebellar transcranial direct current stimulation on craving and relapse in patients with alcohol dependence syndrome: A randomized sham controlled study

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036989

Enrollment

Registered

2021-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: Transcranial Direct Current Stimulation: Study population will be divided in 2 groups. 1.Active group will receive 10 sessions (2 per day) over 5 days,2 mA current and 15 minutes in eac

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients diagnosed with alcohol dependance syndrome as per ICD-10 DCR 2.Absent, minimal, mild to moderate withdrawal (as per CIWA-Ar score 3.Age between 18-50 years. 4. Any gender.

Exclusion criteria

Exclusion criteria: 1.Patients with comorbid dependence syndrome of other substances (excluding nicotine and caffeine) 2.Patients with a diagnosis of any other comorbid psychiatric disorder 3.Patients with alcohol or other substance related psychotic disorder 4.Patients with alcohol related complicated withdrawal (delirium tremens, withdrawal seizure) 5.Patients with metal in cranium, pacemaker 5.Patients with history of significant traumatic brain injury 6.Patients with history of epilepsy and Cerebrovascular Accident (CVA). 7.Patients with confirmed Pregnancy 8.Patients with skin problems, such as dermatitis, psoriasis or eczema over the scalp 9.If there was any serious adverse event following transcranial electric or magnetic stimulation in the past.

Design outcomes

Primary

Measure	Time frame
Craving for Alcohol will be assessed in both active and sham group. Obsessive Compulsive Drinking Scale (OCDS), Alcohol Craving Questionnaire -Short Form-Revised (ACQ-SF-R) and Visual Analog Scale (VAS) will be used for the assessment of craving.Timepoint: 1. Baseline: Just before the delivery of first session at around 8 am (Day 1) 2. After completion of 10 sessions of tDCS. On Day 6, 8am 3. Follow-up: After 6 weeks from the day of last session (either face to face or telephonically)	—

Measure

Time frame

Craving for Alcohol will be assessed in both active and sham group. Obsessive Compulsive Drinking Scale (OCDS), Alcohol Craving Questionnaire -Short Form-Revised (ACQ-SF-R) and Visual Analog Scale (VAS) will be used for the assessment of craving.Timepoint: 1. Baseline: Just before the delivery of first session at around 8 am (Day 1) 2. After completion of 10 sessions of tDCS. On Day 6, 8am 3. Follow-up: After 6 weeks from the day of last session (either face to face or telephonically)

—

Secondary

Measure	Time frame
Adverse effects of tDCS.Timepoint: Adverse effects of tDCS will be checked after every session;Dose requirement of benzodiazepines during detoxificationTimepoint: Cumulative benzodiazepine requirement will be calculated after when CIWA-Ar Score of less than 10 for at least two consecutive days on Benzodiazepine dose equivalent of 4 mg or less.	—

Countries

India

Contacts

Public ContactSusmita Sarkar

All India Institute of Medical Sciences Raipur

singhlokesh123@gmail.com8103624062

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026