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A study to compare the effects of two different drugs (Morphine and Dexmedetomidine) given as spinal anaesthesia to reduce post-operative pain in liver and pancreas surgeries

Comparison of intrathecal morphine versus dexmedetomidine for postoperative analgesia in hepatopancreatic surgeries: A prospective double blinded randomized interventional clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036936
Enrollment
100
Registered
2021-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere Health Condition 2: K769- Liver disease, unspecified

Interventions

Intervention1: Morphine: Intrathecal morphine 4mcg/kg Control Intervention1: Dexmedetomidine: Intrathecal Dexmedetomidine 20mcg

Sponsors

CMC vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing hepatopancreatic surgeries 2. ASA I and II 3. Age >18years

Exclusion criteria

Exclusion criteria: 1. Patient Refusal 2. ASA III and IV 3. Contraindications to spinal Anaesthesia 4. Patients on Beta blockers 5. Known allergy to study drugs.

Design outcomes

Primary

MeasureTime frame
Postoperative pain score assessment using Numerical Rating Scale (NRS)Timepoint: Postoperative pain score assessment using Numerical Rating Scale (NRS) baseline and every Q6h for 48 hours

Secondary

MeasureTime frame
1. Intraoperative hemodynamics 2. Time to awaken 3. Postoperative sedation scores 4. Time to rescue analgesia 5. Time to mobilization Timepoint: 1. Intraoperative hemodynamics baseline,post intrathecal drug,post induction,5 min,30 min,and Q1hrly till end of surgery 2. Time to awaken 3. Postoperative sedation scores Q1hrly for 3 hours and at discharge from recovery. 4. Time to rescue analgesia in 48 hours post surgery 5. Time to mobilization in 48 hours post surgery

Countries

India

Contacts

Public ContactAndrea Grace Oommen

CMC Vellore

tonythomson@cmcvellore.ac.in95002424

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026