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Comparison of lignocaine with placebo on control of blood pressure, heart rate and cough responses to tracheal extubation.

Comparison of three different doses of intravenous lignocaine with placebo on attenuation of haemodynamic and airway responses to tracheal extubation: A double blind randomised prospective study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036911
Enrollment
100
Registered
2021-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Lignocaine (preservative free) 1mg/kg versus 1.5mg/kg versus 2 mg/kg : Lignocaine is an amide local anaesthetic that attenuates the haemodynamic responses to tracheal extubation. Intrav

Sponsors

Sharda Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anaesthesiologists (ASA) physical status I and II 2. Age 18-60yrs 3. Scheduled for elective laproscopic cholecystectomy under general anaesthesia with tracheal intubation.

Exclusion criteria

Exclusion criteria: 1. Refusal to consent 2. Morbid obesity 3. Pregnancy 4. Hypertension 5. History of coronary artery disease 6. History of chronic renal and hepatic disease 7. History of allergy to lignocaine 8. Seizure disorder, 9. Psychiatric disease, 10. Anticipated difficult airway

Design outcomes

Primary

MeasureTime frame
Comparison of three different doses of intravenous lignocaine with placebo on attenuation of haemodynamic and airway responses to tracheal extubation in patients undergoing laparoscopic cholecystectomy under general anaesthesia.Timepoint: Pre-induction, Just before the administration of study drug (T0), 1 min after extubation (T1), 2 mins after extubation (T2), 3 mins after extubation (T3), 4 mins after extubation (T4), 5 mins after extubation (T5), 10 mins after extubation (T10)—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactAnkur Khandelwal

Sharda University School of Medical Sciences & Research

docshaistajamil@gmail.com08750368756

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026