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A trial to study efficacy of methotrexate 1% gel versus betamethasone dipropionate 0.05% lotion in treatment of localized scalp alopecia areata.

Comparison of the efficacy of topical methotrexate 1% gel versus topical betamethasone dipropionate 0.05% lotion in the treatment of localized scalp alopecia areata in a tertiary care institute of Central India: A Randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036887
Enrollment
40
Registered
2021-09-27
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L638- Other alopecia areata

Interventions

Intervention1: Methotrexate 1% gel: 1% gel BD for 12 weeks Control Intervention1: Betamethasone dipropionate: 0.05% lotion BD for 12 weeks

Sponsors

Susmita Banra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age of patients greater than 12 years with localized alopecia areata over scalp. 2.Presence of five or fewer patches of alopecia areata, involving less than 50% scalp area

Exclusion criteria

Exclusion criteria: 1.Patients who have received topical or oral treatment for alopecia areata in the past 1 month. 2.Alopecia areata over areas other than scalp. 3.Presence of ophiasis, diffuse alopecia areata, alopecia totalis and alopecia universalis patients. 4.Other coexisting hair disorder diagnosed based on clinical history and examination (trichotillomania, androgenetic alopecia, telogen effluvium, tinea capitis) 5.Pregnancy 6.Presence of any contraindication or allergy for topical corticosteroids or topical methotrexate. 7.Patient having steroid induced side effects like atrophy, telangiectasia etc. 8.Patients who are not willing to participate.

Design outcomes

Primary

MeasureTime frame
efficacy of topical methotrexate1% gel versus topical betamethasone dipropionate 0.05% lotion in the treatment of localized scalp alopecia areataTimepoint: 4 weeks—

Secondary

MeasureTime frame
side effect profile of topical methotrexate1% gel versus topical betamethasone dipropionate 0.05% lotion in the treatment of localized scalp alopecia areata.Timepoint: 4 weeks—

Countries

India

Contacts

Public ContactDr Neel Prabha

All India Institute of Medical Sciences Raipur

ripuneel@gmail.com8518884782

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026