Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Control Intervention1: Granisetron and Palonosetron: Preoperatively just before induction of anaesthesia group A patients will be given single dose of Palonosetron 1mcg/kg and group B patients single
Sponsors
ABVIMS and Dr Ram Manohar Lohia Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing laparoscopic surgery. ASA grade - 1 and 2 .
Exclusion criteria
Exclusion criteria: 1) Patient having history of motion sickness or past history of PONV 2) Opioid dependence 3) Pregnant females 4) Patients with liver diseases 5) Patients receiving chemotherapy or radiotherapy within the past four weeks. 6) Use of antiemetic drugs within 24 hours prior to surgery. 7) Allergy to any drug used in the study. 8) Patients taking drug which increases serotonin release like selective serotonin reuptake inhibitors ( citalopram, fluoxetine, paroxetine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post operative nausea and vomiting in the first 24 hours following conclusion of anaesthesia Timepoint: In first 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Requirement of rescue antiemetic. 2) Overall satisfaction of patient with nausea and vomiting experience. 3) Occurence of adverse effects like headache, dizziness, drowsiness, injection site pain or reaction etc.Timepoint: After 24 hours | — |
Countries
India
Contacts
Public ContactPriyanka Singh
ABVIMS and Dr RML Hospital
Outcome results
None listed