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Study Comparing Neurocognitive Functions In High Grade Glioma Receiving Radiation post operatively by treatment according to 2 different tumour delineation techniques

Prospective Exploratory Study Comparing Quality of life and Neurocognitive Functions In High Grade Glioma Receiving Post Operative Radiation Based On Two Different Target Volume Delineation Recommendations

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036822
Enrollment
50
Registered
2021-09-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C718- Malignant neoplasm of overlappingsites of brain

Interventions

Intervention1: Radiation: EORTC treatment volume and dose recommendations 60Gray in 30 fractions,5 fractions per week over 6 weeks Control Intervention1: Radiation: RTOG treatment volume and dose reco

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with histologically proven WHO grade III and IV tumours 2. Hb > 10gm%. 3. Pretreatment leucocyte count of > 4000/cu mm 4. Platelet count > 100,000/cu mm 5. Normal renal and liver function tests

Exclusion criteria

Exclusion criteria: 1. Multicentric Glioblastoma 2. Previously treated primary brain tumours 3. Patients with visual disturbances who will not be able to read the questionnaires provided 4. Patients with Alzheimerâ??s disease, Parkinsonâ??s disease, any form of Dementia 5. Contraindications for MRI examination or gadolinium agent use 6. Pregnant or Nursing mothers 7. Any proven 1p19q co-deleted anaplastic oligodendroglioma

Design outcomes

Primary

MeasureTime frame
Neurocognitive functions Timepoint: Assessment at 6 months—

Secondary

MeasureTime frame
Quality of life Progression Free SurvivalTimepoint: Assessment 6 months—

Countries

India

Contacts

Public ContactDeepa Joseph

AIIMS,Rishikesh

drdeepajoseph@yahoo.com8978386509

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026