A study to compare nebulized fentanyl, dexmedetomedine and magnesium sulphate for attenuation of stress response to laryngoscopy and intubation

A prospective, double blinded randomized study to evaluate and compare nebulized fentanyl, dexmedetomedine and magnesium sulphate for attenuation of haemodynamic stress response to laryngoscopy and intubation

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036806

Enrollment

Registered

2021-09-24

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: magnesium sulphate Nebulised 40 mg/kg maximum of 2 g in normal saline with oxygen @ 6 l/m: nebulized form for attenuation of haemodynamic response to laryngoscopy and intubation Interve

Eligibility

Inclusion criteria

Inclusion criteria: Patients between age of 18 and 60 yrs ASA grade 1 and 2 Patients undergoing elective surgery requiring general anaesthesia and endotracheal intubation Mallampati grading I to II

Exclusion criteria

Exclusion criteria: Patient refusal Drug allergy Patient with apparent difficult airway Patients in ASA grade III & above Patients who require Intubation time > 20 sec Patients having BMI >30 Pregnancy

Design outcomes

Primary

Measure	Time frame
To evaluate attenuation of haemodynamic response to laryngoscopy and intubation Timepoint: baseline reading, after nebulisation, 2min, 5min, 10 min after intubation	—

Secondary

Measure	Time frame
adverse effect in anyTimepoint: 2 min 5 min 10 min after intubation	—

Countries

India

Contacts

Public Contactniharika grover

esic medical college and hospital, faridabad

drniharikagroverss@gmail.com9811632907

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026