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Estimating microRNA levels in periodontal disease and their response to non-surgical therapy.

EVALUATION OF SALIVARY AND SERUM microRNA 146a, 200c AND ITS TARGET GENE PTEN IN CHRONIC PERIODONTITIS PATIENTS AND THEIR RESPONSE TO NON-SURGICAL PERIODONTAL THERAPY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036784
Enrollment
120
Registered
2021-09-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Non surgical periodontal therapy (scaling and root planing): miRNAâ??s are a group of small single stranded non-coding RNAâ??s that play a key role in the innate immune responses. The

Sponsors

Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Stage II and Stage III periodontitis patients (4-6mm pocket depth or 3-5 mm loss of attachment) according to the AAP Classification 2018. 2.Patients who have not received periodontal therapy, within preceding six months.

Exclusion criteria

Exclusion criteria: 1.Patients who received treatment with antibiotics/anti-inflammatory drugs in last 3 months. 2.Pregnant and lactating females. 3.Medically compromised patients. 4.Smokers, tobacco chewers and alcoholics. 5.Patients taking high-dose steroid therapy, radiation or immunosuppressive therapy. 6.Mentally retarded and un-cooperative patients. 7.Known history of genetic disorders. 8.Patients not compliant to oral hygiene instructions and recall maintenance.

Design outcomes

Primary

MeasureTime frame
Levels of salivary and serum microRNA 146a, 200c and PTEN gene.Timepoint: Baseline and 8 weeks—

Secondary

MeasureTime frame
1.Sulcus bleeding index ( Muhlemann and Son, 1971) 2.Plaque Index ( Turesky, Gilmore, Glickman modification of Quigley-Hein Plaque Index, 1970) 3.Probing Pocket Depth(PPD) 4.Clinical Attachment Loss(CAL)Timepoint: Baseline and 8 weeks—

Countries

India

Contacts

Public ContactDr JAMMULA SURYA PRASANNA

Panineeya Institute of Dental Sciences and Research Centre

apoorvakunnel@gmail.com9550445743

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026