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Study of squeezing blood out of the umbilical cord and into baby before clamping the cord

A Cluster Randomized Clinical Trial of Umbilical Cord Milking versus Early Cord Clamping on Short and Long-term Outcomes in Neonates Who are Non-Vigorous at Birth - CORDMILK

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036759
Enrollment
3824
Registered
2021-09-22
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P916- Hypoxic ischemic encephalopathy [HIE]

Interventions

Intervention1: Umbilical Cord Milking: The delivering obstetrician will place the newborn below the level of the incision (at the edge of the table) in Caesarean section and a second team member will

Sponsors

National Institute of Child Health and Human Development and The Fogarty International Center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Term and late preterm infants (35-42 weeks gestation) who are non-vigorous at birth that do not meet exclusion criteria will be included 2 Mother willing to participate in the study 3 Mothers age above or equal to 18 years

Exclusion criteria

Exclusion criteria: Infants with congenital malformation of the central nervous system, chromosomal abnormalities, major congenital malformations, complete placental abruption cutting through the placenta at the time of delivery, umbilical knots, inadequate cord length, mono-chorionic twins, twins with no information on amnion or chorion, multiple gestation more than 2 or mother not able to provide consent will be excluded

Design outcomes

Primary

MeasureTime frame
Composite outcome of death and moderate to severe HIE in neonatesTimepoint: Until discharge from the hospital—

Secondary

MeasureTime frame
Improved survival without moderate to severe neurodevelopmental impairmentsTimepoint: At two years of age;Improved survival without brain injury on MRI in infants with moderate to severe HIETimepoint: Performed 5 to 14 days after birth—

Countries

India

Contacts

Public ContactDr S M Dhaded

J N Medical College KAHER Belagavi

drdhadedsm@gmail.com9844232586

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026