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COMPARISON OF NALBUPHINE AND BUPRENORPHINE ADDED TO 0.5%LEVOBUPIVACAINE TO PRODUCE NERVEBLOCK FOR HAND SURGERIES

COMPARATIVE EVALUATION OF NALBUPHINE AND BUPRENORPHINE AS ADJUVANTS TO 0.5%LEVO BUPIVACAINE IN LATERAL APPROACH SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR ELECTIVE UPPER LIMB ORTHOPAEDIC PROCEDURES-A RANDOMISED DOUBLE BLIND STUDY

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036728
Enrollment
60
Registered
2021-09-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M808- Other osteoporosis with current pathological fracture Health Condition 2: M628- Other specified disorders of muscle

Interventions

Intervention1: Group 1-Nalbuphine: Group 1 will receive-nalbuphine 10mg with 0.5ml/kg of 0.5% levobupivacaine-nerve block Control Intervention1: Group 2-Buprenorphine: Group 2 will receive- buprenorp

Sponsors

sapthagiri institute of medical sciences and research center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged between 18 - 60 years 2.Both gender 3.ASA 1 and ASA 2 patients 4.Weight between 40kg -80kg (BMI b/w 23-35kg/m2) 5.Elective upper limb orthopedic surgeries of 1-4hour duration

Exclusion criteria

Exclusion criteria: 1.Patient refusal for regional anaesthesia 2.Allergic to study drug and local anesthetic 3.Patients who have arrhythmia,heart failure,renal failure,liver failure. • 4.H/o Autonomic dysfunction (Diabetic neuropathy) •H/o seizure disorder •H/o Psychiatric illness •With severe broncho pulmonary diseases

Design outcomes

Primary

MeasureTime frame
To compare the efficacy (onset, duration, and post-operative analgesia) of adding nalbuphine versus buprenorphine to levobupivacaineTimepoint: onset of sensory and motor block by pin prick test and modified bromage 2 points score at every 3minutes interval for initial 30 minutes.—

Secondary

MeasureTime frame
To compare amongst these study drugs-The hemodynamic ParametersTimepoint: Haemodynamic parameters: HR,SBP,DBP,MAP,RR,SPO2 at 5minutes interval till the end of surgery.—

Countries

India

Contacts

Public ContactPRAPHULLA R

sapthagiri institute of medical sciences and research center

drmadhumitha99@gmail.com8105196837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026