Comparing Serum Interleukin 15 levels before and after radiofrequency ablation of genicular nerves in knee osteroarthritis patients.

Effect of Radiofrequency Ablation of genicular nerve on serum Interleukin-15 level in knee osteoarthritis :A PROSPECTIVE INTERVENTIONAL STUDY

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036718

Enrollment

Registered

2021-09-21

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Post RFA Serum Interleukin 15 level: Serum IL-15 levels after 15 days of Radiofrequency ablation of genicular nerves. Control Intervention1: Baseline Serum Interleukin 15 levels: Seru

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with symptomatic knee osteoarthritis (OA) that is recalcitrant to conservative modalities. 2.Patients with a failed knee replacement. 3.Patients who are not good surgical candidates because of medical comorbidities and/or a high body mass index (BMI). 4.Patients who want to avoid surgery. 5.Patients who have had a previously successful genicular nerve radiofrequency ablation (GNRFA), as this procedure can be repeated to address recurrent symptomatic knee OA.

Exclusion criteria

Exclusion criteria: 1.Refusal of patient or relatives. 2.Allergic to local anaesthetic and/or radiographic contrast agent. 3.Coagulopathy or patients on anticoagulants. 4.Local site infection. 5.Pregnancy. 6.Severe psychiatric illness. 7.Red flag sign. 8.Acute knee injury. 9.Unstable knee joint. 10.Chronic pain syndrome. 11.Presence of an implantable defibrillator & Presence of a pacemaker.

Design outcomes

Primary

Measure	Time frame
Comparison of Serum interleukin 15 levels pre and post intervention.Timepoint: Baseline and 15 days post intervention	—

Secondary

Measure	Time frame
Comparison of Numerical Rating scores (NRS) pre and post intervention.Timepoint: Baseline, 15 days, 1 month, 3 month post intervention;Comparison of WOMAC pain scores pre and post intervention.Timepoint: Baseline, 15 days, 1 month, 3 month post intervention	—

Countries

India

Contacts

Public ContactDr PRAVEEN TALAWAR

ALL INDIA INSTITUTE OF MEDICAL SCIENCE, RISHIKESH

praveenrt64@gmail.com9654162941

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026