Health Condition 1: PCS- Health Condition 2: K638- Other specified diseases of intestine
Conditions
Interventions
Intervention1: Low fraction of inspired oxygen: Receive inspired 30% oxygen mixed with air
Control Intervention1: High Fraction of inspired oxygen: Receive inspired 80% oxygen mixed with air
Sponsors
All India Institute of Medical Sciences AIIMS Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged more than 60 years and scheduled for elective major surgery of duration more than 2 hours under general anaesthesia will be enrolled.
Exclusion criteria
Exclusion criteria: 1. Patient undergoing cardio-thoracic surgery, thoracotomies 2. Patients with active upper or lower airway infection 3. Patients with abnormal preoperative chest X ?ray findings 4. Patients who are likely to require postoperative mechanical ventilation 5. Morbidly obese patients (BMI-35Kg/m2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence and severity of postoperative atelectasis determined by CT thorax.Timepoint: To compare the incidence and severity of postoperative atelectasis during postoperative period upto 24hrs determined by CT thorax. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare postoperative gas exchange by PaO2/FIO2.Timepoint: before preoxygenation and postoperatively at 1-hour, 6-hours and 12-hours;2.To compare incidence of postoperative nausea and vomiting.Timepoint: 24 hours postoperatively.;3.To compare incidence of surgical site infection.Timepoint: Till 5 days postoperatively.;4.To compare requirement of postoperative respiratory support (oxygen supplementation/ mechanical ventilation).Timepoint: Till day 3 postoperatively.;5.To compare incidence of postoperative pneumonia.Timepoint: Till day 3 postoperatively. | — |
Countries
India
Contacts
Public ContactPradeep Kumar Bhatia
AIIMS Jodhpur
Outcome results
None listed