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can the change in size of large blood vessel in stomach during transiently increasing breath volume predict the response to fluid therapy in seriously ill patients on mechanical ventilator?

Can â??Tidal volume challengeâ?? improve the reliability of inferior vena cava distensibility index in predicting fluid responsiveness in patients ventilated using low tidal volume in prone position? - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036633
Enrollment
40
Registered
2021-09-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome Health Condition 2: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 3: I959- Hypotension, unspecified Health Condition 4: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems Health Condition 5: J189- Pneumonia, unspecified organism Health Condition 6: J99- Respiratory disorders in diseasesclassified elsewhere

Interventions

Intervention1: Tidal volume challenge test: The tidal volume is increased from 6mL/kg Predicted body weight to 8mL/kg PBW and the change in inferior vena cava distensibility index is noted both in sup

Sponsors

Natesh Prabu R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (Age > 18 yrs ) Acute circulatory failure Receiving protective lung ventilation Need of prone ventilation as decided by treating physician.

Exclusion criteria

Exclusion criteria: Acute myocardial infarction Previously known significant valvular disease or intracardiac shunt Air leakage through chest drains Right heart failure An urgently required fluid challenge. Abdominal compartment syndrome, and pregnancy Raised intracranial hypertension Recent Abdominal surgery

Design outcomes

Primary

MeasureTime frame
To determine whether the change inâ?¯Inferior Vena Cava distensibility indexâ?¯â?¯inâ?¯lateral approachâ?¯during â??tidal volume challengeâ?? can reliably predict fluid responsiveness in patients ventilated in prone positionâ?¯â?¯Timepoint: at baseline—

Secondary

MeasureTime frame
To determine whether Inferior Vena Cava -Distensibility index in lateral approach has good correlation and agreement during tidal volume challengeâ?¯in supine and prone positionsTimepoint: immediate;To determine whether Inferior Vena Cava distensibility indexâ?¯inâ?¯subxiphoidâ?¯and lateral approach has good correlation andâ?¯agreement during tidal volume challengeTimepoint: baseline—

Countries

India

Contacts

Public ContactNatesh Prabu R

St Johns Medical College Hospital

drnateshrprabu@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026