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A study to compare efficacy of adding mannitol as an adjunct to lidocaine injection for surgical removal of impacted 3rd molars

ANAESTHETIC EFFICACY OF COMBINATION OF 0.5 M MANNITOL AS AN ADJUVANT WITH LIDOCAINE WITH OR WITHOUT EPINEPHRINE IN INFERIOR ALVEOLAR NERVE BLOCK (IANB) FOR TRANSALVEOLAR EXTRACTION OF IMPACTED MANDIBULAR 3RD MOLARS: A RANDOMIZED CONTROL TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036617
Enrollment
63
Registered
2021-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M263- Anomalies of tooth position of fully erupted tooth or teeth

Interventions

Intervention1: 0.5Mole Mannitol with 2% Lidocaine with or without adrenaline: 0.5Mole Mannitol as an adjunct to local anesthesia with or without adrenaline to increase anaesthetic efficacy. Control In

Sponsors

Dr Priyanka Ganesan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Subjects of both genders â?? needs for mandibular impacted 3rd molar extraction. 2.Above 19 years of age. 3.Patient in good health and not taking any medications that would alter pain perception.

Exclusion criteria

Exclusion criteria: 1.Younger than 18 years of age. 2.Allergies to mannitol, local anaesthetics, or sulphites. 3.Pregnant and Lactating mothers. 4.History of significant medical conditions (ASA CLASS II or higher), taking any medications (over the counter pain relieving medications, narcotics, sedatives antianxiety, or antidepressant medications) which may affect pain assessment. â?? Active pathosis at the site of injection â?? Inability to give informed consent.

Design outcomes

Primary

MeasureTime frame
Increased anaesthetic efficiency by increased duration of action, quicker onset of actionTimepoint: 1min -4hours

Secondary

MeasureTime frame
Return of sensation after procedure indicating efficiency of anaesthesiaTimepoint: 1 week

Countries

India

Contacts

Public ContactDr Sathyanarayanan R

Indira Gandhi Institute Of Dental Sciences

adithyarajam@gmail.com09841495619

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026